Mark M. Davis, Ph.D. is well known for identifying the first T-cell receptor genes, which are responsible for T lymphocytes ability to “see” foreign entities, solving a major mystery in immunology at that time. He and his research group have made many subsequent discoveries about this type of molecule, subsequently, specifically concerning its biochemical properties and other characteristics, including the demonstration that T cells are able to detect and respond to even a single molecule of their ligand-fragments of antigens bound to Major Histocompatibility Complex cell surface molecules. He also developed a novel way of labeling specific T lymphocytes according to the molecules that they recognize, and this procedure is now an important method in many clinical and basic studies of T cell activity, as are other technologies developed by his group. He has authored over 350 publications and received numerous awards and honors for his work, including memberships in the National Academy of Sciences, The National Academy of Medicine and the Royal Society. He is an Investigator with the Howard Hughes Medical Institute, and holds the Avery Family Chair of Immunology at the Stanford University School of Medicine. He has been vice chair and chair of the Department of Microbiology and Immunology at Stanford and, since 2004, The Director of the Institute for Immunity, Transplantation and Infection, which has become an international leader in the development of transformative technologies and approaches to better understanding the human immune system and its responses to infectious diseases and autoimmunity.